High - glucose levels reduce fatty acid oxidation and increase 1 triglyceride accumulation in human placenta
نویسندگان
چکیده
Francisco Visiedo, Fernando Bugatto, Viviana Sánchez, Irene Cózar-Castellano, Jose L. 3 Bartha and Germán Perdomo. 4 Research Unit, University Hospital “Puerta del Mar”, Cádiz, Spain. 5 Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology. 6 University Hospital “Puerta del Mar”, Cádiz, Spain. 7 Instituto de Genética y Biología Molecular (IBGM)-Universidad de Valladolid, Valladolid, 8 Spain. 9 University of Castilla-La Mancha, School of Environmental Sciences and Biochemistry, 10 Toledo, Spain. 11 12 Author for correspondence: 13 Germán Perdomo, Ph.D. 14 University of Castilla-La Mancha, School of Environmental Sciences and Biochemistry. 15 Science-Technology campus in the old Weapons Factory. 16 Sabatini Building. 17 Avenue of Charles III, s/n 18 45071. Toledo. Spain. 19 Tel: (+34) 925268800 Extension 5411 20 e-mail: [email protected] 21 22 Word count: 242 in abstract; 4062 in main text. 23 24 Articles in PresS. Am J Physiol Endocrinol Metab (May 14, 2013). doi:10.1152/ajpendo.00032.2013
منابع مشابه
High glucose levels reduce fatty acid oxidation and increase triglyceride accumulation in human placenta.
Placentas of women with gestational diabetes mellitus (GDM) exhibit an altered lipid metabolism. The mechanism by which GDM is linked to alterations in placental lipid metabolism remains obscure. We hypothesized that high glucose levels reduce mitochondrial fatty acid oxidation (FAO) and increase triglyceride accumulation in human placenta. To test this hypothesis, we measured FAO, fatty acid e...
متن کاملResveratrol reduces lipid accumulation through upregulating the expression of microRNAs regulating fatty acid bet oxidation in liver cells: Evidence from in vivo and in vitro studies
MicroRNAs has been shown to regulate lipogenesis in liver. The aim of the present study was to investigate whether the effects of resveratrol (RSV) on lipogenesis is associated with the changes in the expression of two miRNAs (miR-107 and miR-10b) that regulate lipogenic pathways. 30 wild type C57BL/6j male mice were randomly fed three diets: a standard chow diet (ND), a high fat diet (HFD, 60%...
متن کاملResveratrol reduces lipid accumulation through upregulating the expression of microRNAs regulating fatty acid bet oxidation in liver cells: Evidence from in vivo and in vitro studies
MicroRNAs has been shown to regulate lipogenesis in liver. The aim of the present study was to investigate whether the effects of resveratrol (RSV) on lipogenesis is associated with the changes in the expression of two miRNAs (miR-107 and miR-10b) that regulate lipogenic pathways. 30 wild type C57BL/6j male mice were randomly fed three diets: a standard chow diet (ND), a high fat diet (HFD, 60%...
متن کاملHepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism.
INTRODUCTION To evaluate the impact of the pro-inflammatory cytokine hepatocyte growth factor (HGF) on the regulation of glucose and lipid placental metabolism. METHODS HGF levels were quantified in amniotic fluid and placenta from control and obese women. 2-deoxy-glucose (2-DOG) uptake, glycolysis, fatty acid oxidation (FAO), fatty acid esterification, de novo fatty acid synthesis, triglycer...
متن کاملEffects of Ghrelin on Triglyceride Accumulation and Glucose Uptake in Primary Cultured Rat Myoblasts under Palmitic Acid-Induced High Fat Conditions
This study aimed to study the effects of acylated ghrelin on glucose and triglyceride metabolism in rat myoblasts under palmitic acid- (PA-) induced high fat conditions. Rat myoblasts were treated with 0, 10(-11), 10(-9), or 10(-7) M acylated ghrelin and 0.3 mM PA for 12 h. Triglyceride accumulation was determined by Oil-Red-O staining and the glycerol phosphate dehydrogenase-peroxidase enzymat...
متن کامل